In the late ‘90s begin the first research and studies on the measurement of d-ROMs (pro-oxidant component).
Developed in 1999 the first experimental model of FRAS, which allowed to perform the test on whole blood in a simple way.
In 2000 was developed the model FRAS 2, without printer, mainly made available to Italian researchers (avoiding the need to go through the laboratories).
In 2002, the FRAS 3 model was developed, with printer and centrifuge integrated into the instrument. This was the first instrument designed not only for researchers but also for physicians and medical specialists. FRAS 3 started to be sold also outside Italy in the research field and in Universities.
In 2005 was developed the FRAS 4 model, to which was added the BAP test for the evaluation of the antioxidant component in order to have a complete assessment of oxidative stress in its pro and anti oxidant components.
In 2007 was developed the first software for the interpretation and management of the results of oxidative stress, Win Os Manager.
At the beginning of 2009H&D moved to the new site, located in the immediate vicinity of the city.
In 2009, the FRAS 4 Evolvo was developed to allow serum/plasma testing for greater accuracy with a new housing and new internal software.
Between 2011 and 2012, H&D internalized the production processes for both instrumentation and reagents, obtaining ISO 9001:2008, UNI EN ISO 9001:2008 and ISO 13485:2003 certifications.
In 2012 was developed FRAS 4 Evolvo P, with the introduction of two new tests: the PAT test for the antioxidant component of oxidative stress, precise and executable in only 1 minute (replacing the BAP test, less precise and requiring 5 minutes) and the SAT test to measure the antioxidant component of saliva in 1 minute.
MiniSat, a new system for measuring antioxidant potential in saliva using the SAT test, was developed in 2013.
In 2014 H&D has obtained the UNI EN ISO 13485:2012 certification.
In 2015 was launched FRAS 5, a new system for the evaluation of oxidative stress, where all previous experiences have been carefully applied and improved.
In 2016, FRAS BRAVO, an essential system for testing blood, was launched and the new software for interpretation and management of oxidative stress results, OB Manager, was developed.
In 2018, H&D obtained ISO 9001:2015 and UNI EN ISO 9001:2015 certification and FRAS 5 is equipped with a new software that makes it even more accurate, reliable and responsive to the detection of redox conditions.
In 2019 we obtained ISO 13485:2016 and UNI EN ISO 13485:2016 certification and OB Manager is implemented to achieve even more targeted and satisfactory redox management of patients in clinical practice.
In 2020 it was developed the WellLife test, the first test that evaluates antioxidants in saliva by colorimetric scale and therefore does not require the use of any instrument.
In 2021 it was developed the new search engine for publications on oxidative stress, BibliOs. In addition, the WellLife Check-up is being implemented, which allows for the first check of a person’s state of well-being. The check is done by performing the WellLife test and filling out the WellLife Questionnaire that lead to the final WellLifeReport which indicates the virtuous path to be followed to obtain or maintain the state of well-being.
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